CV
Curriculum Vitae
Name: Shai Shoham
Work address: Department of Research
Herzog Hospital, P.O.Box 35300
Jerusalem 91351, Israel
Telephone: +972-2-5316860
Fax: +972-2-6536075
Email: sshoham@md2.huji.ac.il
Date of Birth: August 28, 1954 Family status: Married + 2
Military Service: 1973-1976
Education: B.A. Psychology 1980, University of Haifa, Israel
M.A. Psychology, 1981, University of Illinois
at Champaign, IL, USA
Ph.D. Psychology, 1984, University of Illinois
at Champaign, IL, USA
Positions held: Postdoctoral fellow in the Department of Physiology of UHS/Chicago Medical School 1984-1985, continued in the Department of Physiology, University of Tennessee at Memphis, 1985-1986.
Visiting scientist, MRC Unit, Molecular Neuroscience at Babraham, Cambridge, UK. 1988.
Current position: Research associate at the department of research at the Sarah Herzog Memorial Hospital, Jerusalem, Israel: Since 1986.
Teaching experience:
1978-1979 University of Haifa, Teaching assistant: Theories of Learning
1979-1984 University of Illinois, Teaching assistant: Techniques in Biological Psychology.
2000- Present Hebrew University, Mount Scopus, Department of
Psychology. Course title: Functional Neuroanatomy
Fellowships awarded:
1986-1987 Raquela Prywes Fellowship from the National Institute of Psychobiology, Israel, for the study of biochemical changes in a rat model of Alzheimer’s disease.
Grants:
1.The Wolfson Family Charitable fund. Subject: Transplantation to animal models of
Alzheimer’s disease. Years: 1987-1989.
2. The European Commission of Communities and the Ministry of Science and
Technology of Israel. Subject: Transplantation of nerve cells to the amygdala in a rat model of Alzheimer’s disease. Years: 1992-1995.
3. The Chief Scientist of the Ministry of Health, Israel. Subject: Manipulation of
endogenous iron and neurotoxicity induced by excitatory amino acids in rat brain. Years: 1996-1997.
4. The National Institute for Psychobiology in Israel. Subject: Effects of nutritional
iron deficiency on hippocampal development in relation to cognitive behavior in rats. Years: 1996-1998.
5. The Israel Science Foundation. Subject: Effects of body weight reduction on
opioid peptides in hippocampus and amygdala and on behavior. Comparison of mouse strains C57BL and DBA/2 and treatment with tyrosine. Years: 1999-2002.
6. The Danone Institute for promotion of nutrition in Israel. Subject: Effects of
tyrosine on brain opioid peptides and on cognitive and emotional behavior after prolonged diet restriction in rats. Years: 1999-2001.
7. The Israel Science Foundation. Subject: Transgenic engineering approach to
investigate the relationship between stereotyped behavior and psychological stress. Years: 2002-2005.
Membership in professional societies
Israel Society for Neuroscience
Israel Society of Biological Psychiatry
Consultant to industry
Alomone Labs, Jerusalem, 02-5871102
Gevys Pharmaceuticals Ltd, Jerusalem, 02-5712338
List of publications in scientific journals:
1. Shoham S. and Teitelbaum P.; Subcortical waking and sleep during lateral
hypothalamic “somnolence” in rats. Physiol. Behav. 28: 323-333, 1982.
2. Walter J., Davenne D., Shoham S., Dinarello C.A. and Krueger J.M.; Brain
temperature changes coupled to sleep states persist during interleukin-1 enhanced sleep. Am. J. Physiol. 250: R96-R103, 1986.
3. Krueger J.M. and Shoham S.; Homologies between sleep factors and hibernation
triggers. In: Living in the Cold, pp. 235-244, H.C. Heller, ed., Elsevier Scientific Publishing Co., New York, 1986.
4. Krueger J.M., Karaszeuski J.W., Davenne D., and Shoham S.; Somnogenic
muramyl peptides. Fed. Proc. 45: 2552-2555, 1986.
5. Krueger J.M., Rosenthal R.S., Martin S.A., Walter J., Davenne D., Shoham S.,
and Kubillus S.L., and Biemann K.; Bacterial peptidoglycans as modulators of sleep: I) Anhydro forms of muramyl peptides enhance somnogenic potency. Brain Res. 403: 249-257, 1987.
6. Krueger J.M., Davenne D., Walter J., Shoham S., Kubillus S.L., Rosenthal R.S.,
Martin S.A., and Biemann K.; Bacterial peptidoglycans as modulators of sleep: II) Effects of muramyl peptides on the structure of rabbit sleep. Brain Res. 403: 258-266, 1987.
7. Krueger J.M., Kubillus S., Shoham S., and Davenne D.; Enhancement of
slow-wave sleep by endotoxin and lipid A. Am. J. Physiol. 251: R591-R597, 1986.
8. Krueger J.M., Dinarello C.A., Shoham S., Davenne D., Walter J., Kubillus S.;
Interferon alpha-2 enhances slow-wave sleep in rabbits. Int. J. Immunopharmacol. 9: 23-30, 1987.
9. Krueger J.M., Shoham S., and Davenne D.; Immunomodulators as promoters of
slow-wave sleep. Clin. Neuropharmacol. 9(suppl. 4): 462-464, 1986.
10. Shoham S., Ahokas R.A., Blatteis C.M., and Krueger J.M.; Effects of muramyl
dipeptide on sleep, body temperature, and plasma copper after intracerebral ventricular administration. Brain Res. 419: 223-228, 1987.
11. Shoham S., Davenne D., Cady A.B., Dinarello C.A., and Krueger J.M.;
Recombinant tumor necrosis factor and interleukin-1 enhance slow-wave sleep in rabbits. Am. J. Physiol. 253: R142-R149, 1987.
12. Shoham S., Davenne D., and Krueger J.M.; Muramyl dipeptide, amphetamine,
and physostigmine: Effects on sleep of rabbits. Physiol. Behav. 41: 179-185, 1987.
13. Shoham S. and Krueger J.M.; Muramyl dipeptide-induced sleep and fever:
effects of ambient temperature and time of injections. Am. J. Physiol. 255: R157-R165, 1988.
14. Shoham S., Blatteis C.M., and Krueger J.M.; Effects of preoptic area lesions on
muramyl dipeptide-induced sleep and fever. Brain Res. 476: 396-399, 1989.
15. Shoham S., Chen Y-.C., DeVietti T.L., and Teitelbaum P.; Deafferentation of
the vestibular organ: Effects on atropine-resistant EEG in rats. Psychobiology 17: 307-314, 1989.
16. Emson P.C., Augood S.J., Buss T.N., Shoham S., Price J., Crossman A.R.,
Marsden C.D.; Studies on the chemical anatomy of the basal ganglia in Parkinson’s disease and in animal models of Parkinson’s disease. In: Parkinsonism and Aging. Calne D.B. ed., Raven Press, New York, 1989, pp. 9-24.
17. Emson P.C., Shoham S., Feler C., Buss T.N., Price J., and Wilson C.J.; The use
of a retroviral vector to identify foetal striatal neurones transplanted into the adult striatum. Exp. Brain Res. 79: 427-430, 1990.
18. Shoham S., Newman M.E., Wertman E., and Ebstein R.P.; Cortical second
messengers after NBM damage: No change in responses to cholinergic agonists. Pharmacol. Biochem. Behav. 36: 507-513, 1990.
19. Shoham S., Wertman E., and Ebstein R.P.; Iron accumulation in the rat basal
ganglia after excitatory amino acid injections – dissociation from neuronal loss. Exp. Neurology 118: 227-241, 1992.
20. Ebstein R.P., Bennett E.R., Sokoloff M., and Shoham S.; The effect of nerve
growth factor on cholinergic cells in primary fetal striatal cultures: Characterization by in situ hybridization. Dev. Brain Res. 73: 165-172, 1993.
21. Ebstein RP, Bennett ER, Shoham S, Sokoloff M Lithium regulation of G protein
mRNA levels in PC12 and GH3 cells: theoretical implications for gene therapy in bipolar illness Gene Ther; 1 Suppl 1:S86, 1994.
22. Shoham S., Glinka Y., Tanne Z., and Youdim M.B.H.; Brain iron: Function and
dysfunction in relation to cognitive processes. In: “Iron Nutrition in Health and Disease”. Leif Hallberg and Neil-Georg Asp, eds., John Libbey & Co., London, England, pp.205-218, 1996.
23. Shoham S., Norris P.J., Baker W.A., and Emson P.C.; Nitric oxide synthase in
ventral forebrain grafts and in early development of ventral forebrain in rats. Developmental Brain Research, 99:155-166, 1997.
24. Shoham S. and Emson P.C.; Effects of combined ventral forebrain grafts to
neocortex and amygdala on behavior of rats with damage to the nucleus basalis magnocellularis. Brain Research Bulletin, 43: 381-392, 1997.
25. Shoham S. and Ebstein R.P.; The distribution of beta amyloid precursor protein
in rat cortex after kainate-induced seizures. Experimental Neurology 147:361-376, 1997.
26. Shoham S., Baker W.A., Norris P.J., and Emson P.C.; Calbindin D28K and
parvalbumin gene expression in rat embryonic ventral forebrain grafts. Experimental Brain Research. 118:551, 1998.
27. Shoham S., Javitt DC, and Heresco-Levy U.; High dose glycine nutrition affects
glial cell morphology in rat hippocampus and cerebellum. International Journal of Neuropsychopharmacology, 2:35-40, 1999.
28. Wormser U, Shoham S, Brodsky B Release of amino acids,
fluorescamine-reactive substances and substance P from the epidermis of the living animal. Skin Pharmacol Appl Skin Physiol, 12:98-104, 1999.
29. Shoham S, Marcus EL, Avraham Y, and Berry E; Diet restriction increases
enkephalin- and dynorphin- like immunoreactivity in rat brain and attenuates long-term retention of passive avoidance. Nutritional Neuroscience, 3: 41-55, 2000.
30. Shoham S, Youdim MB. Iron involvement in neural damage and microgliosis in
models of neurodegenerative diseases. Cell Mol Biol (Noisy-le-grand). 46:743-60, 2000.
31. Sternfeld M, Shoham S, Klein O, Flores-Flores C, Evron T, Idelson GH,
Kitsberg D, Patrick JW, Soreq H. Excess “read-through” acetylcholinesterase attenuates but the “synaptic” variant intensifies neurodeterioration correlates. Proc Natl Acad Sci U S A. 97: 8647-8652, 2000.
32. Shoham S, Javitt DC, Heresco-Levy U Chronic high-dose glycine nutrition:
effects on rat brain cell morphology. Biological Psychiatry, 49(10): 876-85, 2001.
33. Thompson KJ, Shoham S, Connor JR, Iron and neurodegenerative disorders.
Brain Res Bull 55(2): 155-64, 2001.
34. Weinstock M, Kirschbaum-Slager N, Lazarovici P, Bejar C, Youdim MB,
Shoham S, Neuroprotective effects of novel cholinesterase inhibitors derived from rasagiline as potential anti-Alzheimer drugs. Ann N Y Acad Sci 939:148-61, 2001.
35. Cohen, O., Erb, C., Ginzberg, D., Pollak, Y., Seidman, S., Shoham, S., Yirmiya,
R., and Soreq, H. Neuronal overexpression of “readthrough” acetylcholinesterase is associated with antisense-suppressible behavioral impairments. Mol. Psychiatry, 7:874-885, 2002.
36. Shoham S and Youdim MBH. The effects of iron deficiency and iron and zinc
supplementation on rat hippocampus ferritin. J. Neural Transmission. 109: 1241-56, 2002.
37. Birikh KR, Sklan EH, Shoham S and Soreq H Intracellular interaction of
“Readthrough” acetylcholinesterase with RACK1 and protein kinase CβII correlates with intensified fear-induced conflict behavior, Proc Natl Acad Sci U S A., 100(1):283-8, 2003.
38. Weinstock M. and Shoham S. Rat models of dementia based on reductions in
regional glucose metabolism, cerebral blood flow and cytochrome oxidase activity. Journal of Neural Transmission, In press, 2003.
39. Shoham S, Bejar C, Kovalev E, Weinstock M. Intracerebroventricular injection
of streptozotocin causes neurotoxicity to myelin that contributes to spatial memory deficits in rats Exp Neurol. 184(2): 1043-52, 2003.
40. Nijholt I, Farchi N, Kye M, Sklan EH, Shoham S, Verbeure B, Owen D,
Hochner B, Spiess J, Soreq H, Blank T. Stress-induced alternative splicing of acetylcholinesterase results in enhanced fear memory and long-term potentiation. Mol Psychiatry. 9:174-183, 2004.
41. Paschen W, Yatsiv I, Shoham S, Shohami E. Brain trauma induces X-box
protein 1 processing indicative of activation of the endoplasmic reticulum unfolded protein response J Neurochem. 88(4): 983-92, 2004.
Book chapter publications
1. Shoham S. and Ebstein R.P.; Neural transplants in animal models of Alzheimer’s
disease. In: Psychopharmacology of the Elderly (Bergener M., Belmaker R.H., and Tropper M., eds.). Springer, New York, 1993, pp 135-152.
2. Shoham S; Caloric intake during life and its impact on longevity. In: Nutrition for
Longevity (E. Lebenthal, ed.). pages 17-35, ISAS International Seminars Ltd., Jerusalem 2003.
3. Shoham S; Nutrition and preservation of brain function in aging. In: Nutrition for
Longevity (E. Lebenthal, ed.). pages 17-35, ISAS International Seminars Ltd., Jerusalem 2003.
Abstracts
1. Shoham S. and Teitelbaum P.; Identification of subcortical sleep states during
recovery from large hypothalamic lesions in rats. East. Psychol. Assoc. Abstr. 52nd Ann. Meeting. p. 160., 1981.
2. Shoham S., Chesire R., and Teitelbaum P.; Serotonergic blockade diminishes
disconnection of cortical EEG from behavior and releases stepping in lateral hypothalamic damaged rats. Assoc. Psychophys. Study Sleep, 22nd Ann. Meeting. p. 50, 1982.
3. Shoham S., Knight W., and Teitelbaum P.; Stomach distention in recovering
lateral hypothalamic damaged rats induces catalepsy. Soc. Neurosc. Abstr. 8: 900, 1982.
4. Shoham S., Chesire R., and Teitelbaum P.; Pathological- and atropine-induced
high voltage cortical EEG during waking is abolished by serotonergic agonists: replaced by low voltage fast EEG in rats. Sleep Res. 13:28, 1984.
5. Krueger J.M., Walter J., Davenne D., Shoham S., and Dinarello C.A.; Interferon
alpha-2 enhances slow-wave sleep in rabbits. Soc. Neurosc. Abstr. 11:1283, 1985.
6. Shoham S., Davenne D., and Krueger J.M.; Interaction of muamyl dipeptide and
amphetamine: Effects on sleep and brain temperature of rabbits. Soc. Neurosci. Abstr. 12: 156, 1986.
7. Shoham S., Blatteis C.M., Ahokas R.A. and Krueger J.M.; Effects of bilateral
preoptic anterior hypothalamic damage on muramyl dipeptide-induced sleep, fever and hypercupremia. Sleep Res. 16: 145, 1987.
8. Emson P.C., Shoham S., Feler C., Price J., and Wilson C.J.; The use of a
retroviral vector to identify foetal striatal neurones transplanted into the adult striatum. Soc. Neurosci. Abstr. 14(2): 1005, 1988.
9. Shoham S. and Wertman E.; Calbindin D-28K in embryonic basal forebrain grafts
to adult rats. Soc. Neurosci. Abstr. 16(2): 1283, 1990.
10. Shoham S., Ebstein R.P., Stessman J., and Wertman E.; Retrograde tracing
study of NADPH-diaphorase neurons in rat brain. Am. Assoc. Neurol., 1991.
11. Segman R., Shoham S., Ebstein R., and Lerer B.; Genes and the mechanism of
action of ECT: Focus on 5-HT1A receptors. XXth CINP Congress, Melbourne, Australia, 1996.
12. Shoham S., Javitt D.C., and Heresco-Levy U.; Morphological effects of high
dose glycine nutrition in rat brain. Abstracts of the fourth annual meeting of the Israel Society for Biological Psychiatry. Israel Journal of Psychiatry. Vol. 35 (Supplement) 1998.
13. Shoham S, Marcus E, Avraham Y, and Berry EM. Diet restriction increases
enkephalin- and dynorphin- like immunoreactivity in rat brain and reduces long-term retention of passive avoidance. Neuroscience Letters, Suppl. 51, S38, 1998.
14. Shoham S, Javitt DC and Heresco-Levy U. High dose glycine nutrition
selectively affects astrocyte morphology in rat hippocampus and cerebellum. Neuroscience Letters, Suppl. 51, S38, 1998.
15. Shoham S, Sternfeld M, Milai T, Patrick JW and Soreq H. Transgenic human
AchE variants display “corkscrew-like” neuronal processes in mouse somatosensory cortex. Neuroscience Letters, Suppl. 51, S38, 1998.
16. Shoham S, Javitt DC and Heresco-Levy U. High dose glycine supplementation
to rat nutrition – a five-months study exploring effects on brain morphology. Israel Journal of Psychiatry. Vol. 36 (Supplement) 1999.
17. Shoham S and Youdim MBH. Differential sensitivity of hippocampal subregions
to iron deficiency and to iron and zinc nutritional therapy. Neuroscience letters Suppl. 54, S37, 1999.
18. Shoham S and Youdim MBH. Protective effects of iron-deficiency and
interactions of iron with zinc in the kainate model of temporal lobe epilepsy. Neuroscience letters, Suppl. 54, S37, 1999.
19. Albahari D, Shoham S, Renbaum P, Levy-Lahad E and Soreq H. Presenilin-1
mRNA is detected in dendrites of purkinje cells by in situ hybridization. Neuroscience letters, Suppl. 54, S2, 1999.
20. Klein O, Sternfeld M, Shoham S, Evron T, Idelson GH, Kitsberg D, Patrick JW
and Soreq H. Neuropathologies indicative of stress are intensified by inherited excess of synaptic AChE but suppressed by “readthrough” AChE. Neuroscience letters, Suppl. 54, S24, 1999.
21. Shoham S, Bejar C and Weinstock M. Protective effects of TV3326 against
neuronal damage and spatial memory deficits induced in rats by intracerebroventricular injection of streptozotocin. Neuroscience letters Suppl. 5, S52, 2000.
22. Shoham S, Kovalev E, Marcus EL, Sternfeld M, Berry EM and Soreq H.
Transgenic acetylcholinesterase over-expression increases weight loss response to dietary restriction. Neuroscience letters. Suppl. 5, S52, 2000.
23. Shoham S, Kovalev E, Marcus EL, Avraham Y, and Berry EM. Tyrosine
nutritional suppplementation: effects on behavior in diet restricted female C57BL mice. Neuroscience letters. Suppl. 5, S52, 2000.
24. Sklan E, Birikh KR, Shoham S, and Soreq H. The C-terminal domain of
“readthrough” acetylcholinesterase interacts with RACK1, the WD family member PKC intracellular receptor. Neuroscience letters. Suppl. 5, S53, 2000.
25. Shoham S, Kovalev E, Marcus EL, Sternfeld M, Berry EM, and Soreq H.
Transgenic acetylcholinesterase variants affect body weight and the response to dietary restriction in mice. Israel J. of Psychiatry. 38: 22, 2001.
26. Shoham S, Kovalev E, and Soreq H. Transgenic overexpression of the
readthrough variant of acetylcholinesterase induces stereotypic behavior in FVB/N mice. Israel J. of psychiatry 39: 15, 2002.
